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Sequence Type 4821 Clonal Complex Serogroup B Neisseria meningitidis in China, 1978-2013

Bingqing Zhu, Zheng Xu, Pengcheng Du

    Emerging Infectious Diseases
    |May 20, 2015
    PubMed

    Insights

    Serogroup C Neisseria meningitidis CC4821 likely originated the hyperinvasive serogroup B strains. Genomic analysis revealed shared genotypes and close evolutionary relationships between serogroup B and C strains.

    Area of Science:

    • Microbiology
    • Genomics
    • Epidemiology

    Background:

    • The hyperinvasive Neisseria meningitidis sequence type 4821 clonal complex (CC4821) was initially identified in serogroup C strains.
    • Increasing isolation of serogroup B CC4821 strains in China necessitates understanding their origin.

    Observation:

    • Outer membrane protein genes (PorA, PorB, FetA) were characterized in 48 serogroup B and 214 serogroup C CC4821 strains.
    • Genomic sequencing of 22 CC4821 strains revealed close clustering of serogroup B and C strains within two phylogenetic groups.

    Findings:

    • Four serogroup B strains exhibited identical PorA, PorB, and FetA genotypes to serogroup C strains.
    • Serogroup B strains displayed variability at the capsule locus, indicating recombination events.

    Implications:

    • The findings suggest a serogroup C Neisseria meningitidis CC4821 origin for the emerging pathogenic serogroup B strains.
    • Understanding the genetic exchange and evolution of meningococcal CC4821 is crucial for public health surveillance and vaccine development.
    Keywords:
    CC4821ChinaNeisseria meningitidisST-4821 clonal complexbacteriacapsule switchingclonal complex 4821epidemicepidemiologyphylogenetic analysisrecombination eventssequence type 4821serogroup Bserogroup Csurveillance

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