Related Experiment Video
Updated: Apr 12, 2026

Tissue Engineering of the Intestine in a Murine Model
Published on: December 1, 2012
Repairing organs: lessons from intestine and liver
Helmuth Gehart1, Hans Clevers1
1Hubrecht Institute - Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT Utrecht, The Netherlands.
Abstract:
The concept of organ regeneration has fascinated humanity from ancient mythology to modern science fiction. Recent advances offer the potential to soon bring such technology within the grasp of clinical medicine. Rapidly expanding insights into the intrinsic repair processes of the intestine and liver have uncovered significant plasticity in epithelial tissues. Harnessing this knowledge, researchers have recently created culture systems that enable the expansion of stem cells into transplantable tissue in vitro. Here we discuss how the growing tool set of stem cell biology can bring organ repair from fictitious narrative to medical practice.
Related Concept Videos
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Tissue Renewal without Stem Cells
However, failure of such a system...
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...

