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Computer analysis of saccadic eye movements: assessment of two different carbamazepine formulations
G Tedeschi1, G Casucci, S Allocca
1Institute of Neurological Sciences, First Faculty of Medicine, University of Naples, Italy.
European Journal of Clinical Pharmacology
|January 1, 1989
Abstract:
The central effects of two different formulations of Carbamazepine (CBZ) have been examined by analysis of saccadic eye movements (SEM) in 6 healthy volunteers, who took part in a double-blind, latin-square, placebo controlled study. Both a conventional- and a controlled-release formulation of CBZ produced a significant effect on peak saccadic velocity and saccade accuracy, but only the former affected saccade latency. Computer analysis of SEM confirmed it to be a highly sensitive method for detection of subclinical drug effects on the CNS.