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Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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NMDA receptor binding in focal epilepsies

C J McGinnity1, M J Koepp2, A Hammers3

  • 1Division of Neuroscience, Department of Medicine, Imperial College London, London, UK Medical Research Council Clinical Sciences Centre, London, UK Division of Imaging Sciences & Biomedical Engineering, Faculty of Life Sciences & Medicine, King's College London, London, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|May 21, 2015
PubMed
Summary

Positron emission tomography (PET) with [(18)F]GE-179 revealed increased N-methyl-d-aspartate (NMDA) receptor availability in focal epilepsy patients. Antidepressant use was associated with reduced NMDA receptor availability, suggesting a potential therapeutic mechanism.

Keywords:
DEPRESSIONEPILEPSYNMDAPET

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