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Telocyte dynamics in psoriasis.

C G Manole1,2, Mihaela Gherghiceanu2, Olga Simionescu3

  • 1Department of Cell Biology and Histology, 'Carol Davila' University of Medicine and Pharmacy, Bucharest, Romania.

Journal of Cellular and Molecular Medicine
|May 21, 2015
PubMed
Summary
This summary is machine-generated.

Telocytes (TCs), crucial for skin health, are significantly reduced and degenerated in psoriasis vulgaris. This impairment of TCs may explain psoriasis

Keywords:
Auspitz's signLangerhans cellsTelocytesangiogenesisdendritic cellspapillary dermispsoriasis

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Area of Science:

  • Dermatology and Cell Biology
  • Investigating interstitial cells in skin pathology
  • Understanding cellular contributions to inflammatory skin diseases

Background:

  • Telocytes (TCs) are distinct interstitial cells in human dermis, forming a 3D network involved in skin homeostasis and repair.
  • Previous studies noted TC alterations in systemic scleroderma, highlighting their role in skin conditions.
  • Psoriasis pathogenesis often focuses on epidermal changes, potentially overlooking dermal contributions.

Purpose of the Study:

  • To investigate the presence, distribution, and ultrastructure of telocytes (TCs) in the dermis of patients with psoriasis vulgaris.
  • To compare TC characteristics in psoriatic lesions versus uninvolved and treated skin.
  • To explore the potential role of TCs in the vascular pathology of psoriasis.

Main Methods:

  • Immunohistochemistry (IHC) and immunofluorescence (IF) to identify CD34/PDGFRα-positive TCs.
  • Transmission electron microscopy (TEM) for ultrastructural analysis of TCs and surrounding vasculature.
  • Comparative analysis of TCs in psoriatic, uninvolved, and treated skin samples.

Main Results:

  • CD34/PDGFRα-positive TCs were identified in the papillary dermis, forming a 3D network near blood vessels in healthy and treated skin.
  • A significant decrease in TC number and presence of degenerative features (apoptosis, fragmentation) were observed in psoriatic plaques.
  • Impaired TCs were associated with altered vascular smooth muscle cells and may explain psoriasis' vascular pathology and Auspitz's sign.

Conclusions:

  • Telocytes (TCs) are significantly diminished and exhibit degenerative changes in psoriatic dermis.
  • The loss of protective TC envelopes around blood vessels contributes to psoriasis-associated vascular pathology.
  • TCs represent a potential novel cellular target for future psoriasis therapies.