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Cardiac perfusion imaging using hyperpolarized (13)C urea using flow sensitizing gradients.

Angus Z Lau1,2, Jack J Miller2,3, Matthew D Robson1

  • 1Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, United Kingdom.

Magnetic Resonance in Medicine
|May 21, 2015
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Summary

This study shows a new way to image hyperpolarized carbon-13 urea in the rodent heart. It successfully visualizes myocardial perfusion, aiding in the identification of metabolism and perfusion mismatches.

Keywords:
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Area of Science:

  • Cardiovascular Imaging
  • Magnetic Resonance Imaging
  • Hyperpolarized Contrast Agents

Background:

  • Assessing myocardial perfusion is crucial for diagnosing cardiac conditions.
  • Current imaging techniques may face challenges in differentiating blood pool signal from tissue uptake.
  • Hyperpolarized (13)C urea offers potential for metabolic and perfusion imaging.

Purpose of the Study:

  • To demonstrate the feasibility of imaging the first passage of hyperpolarized (13)C urea in the rodent heart.
  • To develop flow-sensitizing gradients to minimize blood pool signal.
  • To enable improved visualization of myocardial perfusion.

Main Methods:

  • Optimized a flow-sensitizing bipolar gradient to reduce cardiac chamber signal.
  • Integrated the gradient into a dynamic golden angle spiral (13)C imaging sequence.
  • Scanned healthy rats at rest and during adenosine stress-induced hyperemia.

Main Results:

  • Achieved dynamic imaging of hyperpolarized (13)C urea's first passage in the rodent heart.
  • Successfully reduced signal contamination from the cardiac lumen.
  • Detected a two-fold increase in myocardial perfusion during hyperemia, indicating a perfusion reserve of two.

Conclusions:

  • The novel pulse sequence enables clear imaging of hyperpolarized (13)C urea in the rodent heart.
  • This technique allows for the identification of cardiac metabolism/perfusion mismatches.
  • Opens avenues for advanced hyperpolarized (13)C MRI studies in cardiovascular research.