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Related Experiment Video

Updated: Apr 12, 2026

Use of the Scissor-Type Knife During the Peroral Endoscopy Myotomy Procedure for the Treatment of Achalasia
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Peroral endoscopic myotomy.

Vivek Kumbhari1, Mouen A Khashab1

  • 1Vivek Kumbhari, Mouen A Khashab, Department of Medicine and Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, MD 21205, United States.

World Journal of Gastrointestinal Endoscopy
|May 21, 2015
PubMed
Summary
This summary is machine-generated.

Peroral endoscopic myotomy (POEM) is an effective endoscopic procedure for achalasia and spastic esophageal disorders, showing high short-term success rates with minimal risks. Further research is ongoing to optimize techniques and explore its use in gastroparesis.

Keywords:
AchalasiaDysphagiaMyotomyPeroral endoscopic myotomy

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Area of Science:

  • Gastroenterology and Endoscopic Surgery
  • Esophageal Motility Disorders

Background:

  • Peroral endoscopic myotomy (POEM) is an advanced endoscopic technique utilizing a submucosal tunnel.
  • It is primarily used for achalasia palliation but shows efficacy in spastic esophageal disorders.

Purpose of the Study:

  • To review the efficacy and safety of POEM for esophageal motility disorders.
  • To discuss the technical aspects, outcomes, and emerging applications of POEM.

Main Methods:

  • Review of existing data on POEM for achalasia and spastic esophageal disorders.
  • Analysis of short-term response rates, adverse events, and long-term outcomes.
  • Exploration of POEM's application in gastroparesis.

Main Results:

  • POEM achieves short-term response in 82-100% of patients with minimal adverse events.
  • The procedure is safe and effective across different age groups and prior treatment histories.
  • Major late adverse event is gastroesophageal reflux (20-46%); intraprocedural adverse event management is critical.

Conclusions:

  • POEM is a paradigm shift in managing esophageal motility disorders, demonstrating high efficacy and safety.
  • Ongoing research focuses on technique optimization and personalized approaches.
  • POEM shows promise for gastroparesis management, with long-term trial data anticipated.