High fat diet-induced obesity increases the formation of colon polyps induced by azoxymethane in mice
Related Experiment Video For Obesity-associated colon cancer
Updated: Apr 12, 2026
Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
Published on: September 11, 2012
Jiezhong Chen1, Xu-Feng Huang1
11 Illawarra Health and Medical Research Institute, University of Wollongong, Northfields Avenue, NSW 2522, Australia ; 2 School of Biomedical Sciences, University of Queensland, St Lucia, QLD 4072, Australia.
Background:
Obesity has been found to be associated with colon cancer. However, the mechanism of this relationship is unclear and thus a good animal model is required. Our previous research showed that some mice developed diet-induced obesity (DIO) whilst others were diet-resistant (DR) when fed a high-fat diet.
Methods:
In the present study, we have tested the effects of a high-fat diet on the formation of colon polyps induced by azoxymethane (AOM) in both DIO and DR mice.
Results:
We found that the DIO mice have developed 2.5 times of polyps compared to the DR mice (P<0.05) and 3.4 times of polyps compared to the low fat fed mice (P<0.05). Although the DR mice tended to have more polyps than the low-fat diet fed mice, this was not statistically significant. The DIO mice could have an increased polyp formation due to obesity-related cancer risk factors and different gene expression from DR mice.
Conclusions:
DIO mice could be used as an appropriate model for studying obesity-associated colon cancer; however DR mice are not suitable because they don't show any significant weight gains to indicate obesity.
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