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Updated: Apr 12, 2026
Stimulus-specific Cortical Visual Evoked Potential Morphological Patterns
Published on: May 12, 2019
Visual evoked potentials show strong positive association with intracranial pressure in patients with cryptococcal
Marcelo Adriano da Cunha Silva Vieira1, Maria do Amparo Salmito Cavalcanti1, Dorcas Lamounier Costa2
1Departamento de Neurologia, Instituto de Doenças Tropicais Natan Portella, Teresina, PI, Brazil.
Objective:
To verify the relationship between intracranial pressure and flash visual evoked potentials (F-VEP) in patients with cryptococcal meningitis. Method The sample included adults diagnosed with cryptococcal meningitis admitted at a reference hospital for infectious diseases. The patients were subjected to F-VEP tests shortly before lumbar puncture. The Pearsons linear correlation coefficient was calculated and the linear regression analysis was performed.
Results:
Eighteen individuals were subjected to a total of 69 lumbar punctures preceded by F-VEP tests. At the first lumbar puncture performed in each patient, N2 latency exhibited a strong positive correlation with intracranial pressure (r = 0.83; CI = 0.60 - 0.94; p < 0.0001). The direction of this relationship was maintained in subsequent punctures.
Conclusion:
The intracranial pressure measured by spinal tap manometry showed strong positive association with the N2 latency F-VEP in patients with cryptococcal meningitis.
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