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Applying the ARRIVE Guidelines to an In Vivo Database.

Natasha A Karp1, Terry F Meehan2, Hugh Morgan3

  • 1Mouse Informatics Group, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.

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The ARRIVE guidelines enhance reproducibility in animal research. Applying these transparent reporting standards to the International Mouse Phenotyping Consortium (IMPC) improves data integrity for mouse knockout studies.

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Area of Science:

  • Biomedical research
  • Animal studies
  • Data management

Background:

  • Reproducibility is a challenge in biomedical animal research.
  • Transparent reporting is crucial for in vivo databases.
  • The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines aim to improve reporting standards.

Purpose of the Study:

  • To describe the benefits and challenges of applying ARRIVE guidelines to the International Mouse Phenotyping Consortium (IMPC).
  • To ensure transparency and reproducibility within the IMPC.
  • To provide a resource for similar initiatives.

Main Methods:

  • Application of ARRIVE guidelines principles to the IMPC database.
  • Analysis of benefits and challenges encountered during implementation.
  • Development of solutions for identified challenges.

Main Results:

  • Successful application of ARRIVE principles enhances transparency and reproducibility in large-scale mouse phenotyping.
  • Identified specific challenges in applying guidelines to a multi-center database.
  • Developed practical solutions to overcome these challenges.

Conclusions:

  • Implementing ARRIVE guidelines is beneficial for large-scale in vivo research consortia like IMPC.
  • Addressing challenges in guideline application can create valuable resources for the scientific community.
  • Transparent reporting is essential for robust and reproducible animal research.