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Updated: Apr 12, 2026
06:45
Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
Published on: May 2, 2025
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Negative pressure wound therapy for treating pressure ulcers.
Jo C Dumville1, Joan Webster, Debra Evans
1School of Nursing, Midwifery and Social Work, University of Manchester, Manchester, UK, M13 9PL.
The Cochrane Database of Systematic Reviews
|May 21, 2015
Summary
Negative pressure wound therapy (NPWT) shows no proven benefit for treating pressure ulcers due to a lack of high-quality evidence. More rigorous research is needed to determine its effectiveness and safety for pressure injury management.
Area of Science:
- Wound healing research
- Clinical effectiveness studies
Background:
- Pressure ulcers, also known as pressure injuries, are localized skin and tissue damage.
- Negative pressure wound therapy (NPWT) is a potential treatment for pressure ulcers.
Purpose of the Study:
- To assess the effects of NPWT for treating pressure ulcers across all care settings.
- To evaluate the evidence for NPWT in pressure ulcer management.
Main Methods:
- Searched multiple databases (Cochrane, MEDLINE, EMBASE, CINAHL) in May 2015.
- Included randomized controlled trials (RCTs) comparing NPWT with alternative treatments for stage II+ pressure ulcers.
- Two authors independently performed study selection, risk of bias assessment, and data extraction.
Main Results:
- Four studies with 149 participants were included, comparing NPWT with dressings, gels, or moist wound healing.
- Three studies had a high risk of bias, and all evidence was of very low quality.
- Only one study reported usable wound healing data, with minimal positive outcomes and limited data on adverse events.
Conclusions:
- There is a lack of rigorous RCT evidence on the effectiveness of NPWT for pressure ulcers.
- High uncertainty remains regarding the benefits and harms of NPWT in pressure ulcer management.
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