Bioinspired Titanium Drug Eluting Platforms Based on a Poly-β-cyclodextrin-Chitosan Layer-by-Layer Self-Assembly...

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Infectious Disease Treatment

Background:

• Postoperative infections and inflammation are common complications with titanium-based implants.
• Polyelectrolyte multilayers (PEMs) offer a promising method for controlled local drug delivery from implants.
• Transforming medical implants into drug delivery systems can significantly improve patient outcomes.

Purpose of the Study:

• To design and develop novel biodegradable, multidrug-eluting titanium platforms using bioactive polyelectrolyte multilayer coatings.
• To create a robust coating system that targets and prevents implant-associated infections.
• To investigate the potential of these platforms as advanced drug delivery systems for therapeutic applications.

Main Methods:

• Utilized layer-by-layer (L-b-L) assembly to create PEMs with a synthetic β-cyclodextrin-based polymer (PCD) as a drug reservoir and chitosan (CHT) as a control barrier.
• Employed a bioinspired polydopamine (PDA) interlayer for strong adhesion of PEMs to the titanium surface.
• Characterized PEMs using Surface Plasmon Resonance (SPR), colorimetric titrations, gravimetric analyses, Scanning Electron Microscopy (SEM), profilometry, and ellipsometry.
• Validated drug-eluting capabilities and anti-infective properties using gentamicin.

Main Results:

• Successfully engineered biodegradable PEMs with 5, 10, and 15 bilayers on titanium surfaces.
• Demonstrated robust attachment of PEMs via the PDA interlayer.
• Characterized multilayer film growth, morphology, thickness, and degradation in physiological conditions.
• Validated the gentamicin-eluting capacity of the coated titanium devices for infection treatment.

Conclusions:

• Developed a versatile, biodegradable, multidrug-eluting titanium platform using PEMs for targeted infection control.
• The PDA-PEM coating strategy provides a robust and adaptable method for creating advanced biomaterial implants.
• These innovative platforms hold significant potential for transforming implantable devices into effective localized drug delivery systems, reducing postoperative complications.