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Conventional Repetitive Transcranial Magnetic Stimulation for Depression: A Step-by-Step Protocol

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Systemic treatment: maintenance compared with holiday.

Cornelis J A Punt¹, Lieke H J Simkens¹, Miriam Koopman¹

¹From the Department of Medical Oncology, Academic Medical Centre, University of Amsterdam, Amsterdam, Netherlands; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht, Netherlands.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting

|May 21, 2015

Summary

For metastatic colorectal cancer (mCRC), optimal drug use and treatment duration remain unclear. While oxaliplatin interruption is feasible, full chemotherapy breaks need more study, and anti-EGFR agent duration is unknown.

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The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

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Published on: July 11, 2013

Area of Science:

Oncology
Medical Pharmacology

Background:

Metastatic colorectal cancer (mCRC) management involves cytotoxic and targeted drugs.
Optimal drug sequencing and treatment duration for mCRC are not fully established.
Chemotherapy-free intervals in mCRC have yielded conflicting results.

Purpose of the Study:

To review current data on treatment interruptions and maintenance strategies for mCRC.
To evaluate the safety of interrupting oxaliplatin-based chemotherapy.
To assess the optimal duration for targeted therapies, including anti-EGFR agents.

Main Methods:

Review of existing clinical data and studies on systemic treatments for mCRC.
Analysis of findings regarding chemotherapy interruptions and maintenance therapies.
Examination of theoretical benefits of continuous targeted therapy.

Main Results:

Oxaliplatin interruption appears safe, but definitive conclusions on full chemotherapy breaks are lacking.
Maintenance treatment with chemotherapy and bevacizumab is supported by recent data.
No data currently exist on the optimal treatment duration for anti-EGFR agents in mCRC.

Conclusions:

Further research is needed to define optimal treatment strategies and durations for mCRC.
The safety and efficacy of chemotherapy-free intervals require more investigation.
Optimal use of targeted therapies, especially anti-EGFR agents, needs clarification.