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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
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Left Atrial Function in Patients with Chronic Chagasic Cardiomyopathy

Claudia da Silva Fragata1, Afonso Y Matsumoto2, Felix J A Ramires2

  • 1Seção Médica de Eletrofisiologia, Instituto Dante Pazzanese de Cardiologia, São Paulo, BR.

Arquivos Brasileiros De Cardiologia
|May 21, 2015
PubMed

Insights

Left atrial function is impaired in Chagas cardiomyopathy, particularly in patients with left ventricular dysfunction. Echocardiography reveals reduced reservoir, conduit, and pump functions, correlating with diastolic parameters.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Chagas Disease Research

Background:

  • Chagas disease is a significant cause of dilated cardiomyopathy.
  • Left atrial (LA) function in Chagas cardiomyopathy remains understudied.

Purpose of the Study:

  • To evaluate reservoir, conduit, and pump functions of the left atrium.
  • To correlate LA functions with left ventricular (LV) systolic and diastolic parameters in Chagas disease patients.

Main Methods:

  • Echocardiographic assessment including M-mode, 2D, pulsed-wave Doppler, and tissue Doppler imaging.
  • Study included 10 controls and 65 patients with Chagas disease categorized into indeterminate, ECG alteration, and LV dysfunction groups.

Main Results:

  • Significant impairment of LA reservoir (Total Emptying Fraction), conduit (Passive Emptying Fraction), and pump (Active Emptying Fraction) functions observed in patients with LV dysfunction.
  • Negative correlation found between E/e' and LA reservoir/pump functions; positive correlation between e' and LA reservoir, conduit, and pump functions.

Conclusions:

  • Left atrial function is demonstrably impaired in Chagas cardiomyopathy.
  • Echocardiographic parameters reflect the extent of LA dysfunction in this condition.
Abstract

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