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Insulin resistance, dyslipidemia and cardiovascular changes in a group of obese children

António Pires1, Paula Martins1, Ana Margarida Pereira2

  • 1Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Arquivos Brasileiros De Cardiologia
|May 21, 2015
PubMed

Insights

Pediatric obesity is linked to early cardiovascular risks. Key markers of adiposity correlate with metabolic issues and cardiac changes in children, aiding risk stratification.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Research
  • Metabolic Syndrome

Background:

  • Childhood obesity presents significant risks for developing adult cardiovascular disorders.
  • Obesity-related comorbidities in children establish a foundation for early onset of cardiovascular diseases.

Purpose of the Study:

  • To investigate the relationship between adiposity markers and metabolic disturbances.
  • To correlate adiposity markers with vascular and cardiac morphology in European pediatric obese patients.

Main Methods:

  • Observational, transversal analysis of 121 obese children (ages 6-17) and 40 normal-weight controls.
  • Analysis included adiposity markers, plasma lipids, homeostasis model assessment-insulin resistance (HOMA-IR), carotid intima-media thickness (cIMT), and left ventricular (LV) dimensions.
  • Compared obese children to a control group with normal body mass index (BMI).

Main Results:

  • Obese children showed significantly higher levels of most analyzed variables compared to controls, except for age, HDL cholesterol, and adiponectin.
  • In obese children, BMI correlated directly with LV mass (r=0.542), HOMA-IR (r=0.378), and mean cIMT (r=0.378).
  • Insulin resistance affected 38.1% of obese children, 12.5% had dyslipidemia, and eccentric hypertrophy was the predominant LV geometric pattern.

Conclusions:

  • Identified key correlations between adiposity markers, metabolic disturbances, and cardiac/vascular changes in pediatric obesity.
  • These findings suggest potential clinical utility for these markers in cardiovascular risk stratification for children.
  • The study highlights the importance of assessing these markers for evaluating the effectiveness of weight management interventions.
Abstract

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