[Genetic analysis of complementation of t-haplotypes in mice]

Complementation for viability of the compounds tx/ty in complete lethal haplotypes t6, t12, tw5, tw12, tw18, tw73, twPa-1 belonging to the seven basic complementation groups was studied. In the overwhelming majority of crosses a lack of tx/ty offspring was revealed but there is also evidence of non-complete complementation of the tx/ty haplotypes, except for T/tw73XT/tw12, T/tw18XT/t12, T/tw73XT/tw18 crosses in which the level of complementation for viability exceeds 100%. The maternal effect for compound variability was significantly revealed in 9 out of the 19 matings. In addition, reciprocal matings of heterozygotes T/txXT/ty were tested for fertility. In two cases, the maternal effect was also revealed for this character. Comparison of data on viability of the compounds and the fertility of the original strains gives grounds to believe that the tx/ty haplotypes are not completely recessive and partially manifest themselves in the heterozygotes, decreasing fertility in a number of matings. In some cases, these t-haplotypes yield an effect, close to negative complementation, which may be associated with the interaction of the proteins of t-haplotypes.