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Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen
Linh Thuy Nguyen1, Linda Dunford2, Ines Freitas3
1Ireland Vietnam Blood-Borne Virus Initiative, Dublin, Ireland, and Hanoi, Vietnam Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin, Belfield, Ireland Laboratory for Molecular Diagnostics, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam crid.office@ucd.ie.
Abstract:
Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic.
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