Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neuroplasticity01:01

Neuroplasticity

2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

2.9K
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
2.9K
Long-term Potentiation01:25

Long-term Potentiation

3.9K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.9K
Long-term Potentiation01:35

Long-term Potentiation

59.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
59.6K
Long-term Depression01:03

Long-term Depression

3.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.6K
Long-term Depression01:05

Long-term Depression

33.8K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glycoprotein Hydrogen-Bonding Hypothesis and Its Relationship with Other Mechanisms of Molecular Memory.

Current medicinal chemistry·2026
Same author

Quantum Consciousness: A Molecular Perspective Involving Glycoprotein-Tunnelling Hypothesis (GPTH).

Current medicinal chemistry·2026
Same author

A Unified Model of Consciousness: Glycoprotein Patterns in Memory Processes and Quantum Entanglement.

Current medicinal chemistry·2025
Same author

A modular inquiry-based semester theme that integrates data science education and bioinformatics in protein structure function courses.

FEMS microbiology letters·2024
Same author

Biochemical and <i>In Silico</i> Studies on Triazole Derivatives as Tyrosinase Inhibitors: Potential Treatment of Hyperpigmentation Related Skin Disorders.

Medicinal chemistry (Shariqah (United Arab Emirates))·2024
Same author

Diclofenac prodrugs nanoparticles: An alternative and efficient treatment for rheumatoid arthritis?

International journal of pharmaceutics·2023

Related Experiment Video

Updated: Apr 12, 2026

Whole-cell Patch-clamp Recordings in Brain Slices
07:23

Whole-cell Patch-clamp Recordings in Brain Slices

Published on: June 15, 2016

63.3K

Neural plasticity and memory: molecular mechanism.

Zareen Amtul, Atta-Ur-Rahman

    Reviews in the Neurosciences
    |May 22, 2015
    PubMed
    Summary

    Understanding memory storage requires detailed synapse-level analysis. Current models of short-term and long-term memory storage need further molecular and chemical investigation at individual synapses.

    Area of Science:

    • Neuroscience
    • Molecular Biology
    • Cellular Biology

    Background:

    • Memory formation involves synaptic alterations.
    • Existing models focus on posttranslational modifications and mRNA translation for memory storage.
    • A detailed synapse-level summary of these modifications is lacking.

    Purpose of the Study:

    • To describe the spatiotemporal reorganization of synaptic plasticity at the dendritic spine level.
    • To elucidate the mechanisms of synaptic substructure remodeling.
    • To highlight the need for further molecular investigation into memory storage.

    Main Methods:

    • Review and synthesis of current literature on synaptic plasticity and memory storage.
    • Focus on dendritic spine level analysis.

    More Related Videos

    Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
    07:17

    Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

    Published on: June 23, 2022

    3.1K
    3D Modeling of Dendritic Spines with Synaptic Plasticity
    07:13

    3D Modeling of Dendritic Spines with Synaptic Plasticity

    Published on: May 18, 2020

    7.5K

    Related Experiment Videos

    Last Updated: Apr 12, 2026

    Whole-cell Patch-clamp Recordings in Brain Slices
    07:23

    Whole-cell Patch-clamp Recordings in Brain Slices

    Published on: June 15, 2016

    63.3K
    Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans
    07:17

    Aversive Associative Learning and Memory Formation by Pairing Two Chemicals in Caenorhabditis elegans

    Published on: June 23, 2022

    3.1K
    3D Modeling of Dendritic Spines with Synaptic Plasticity
    07:13

    3D Modeling of Dendritic Spines with Synaptic Plasticity

    Published on: May 18, 2020

    7.5K
  • Exploration of molecular and structural alterations at synapses.

    • Main Results:

    • Synapses store cognitive information through molecular and structural changes.
    • Posttranslational modifications are key for short-term memory, while mRNA translation is crucial for long-term memory.
    • The precise molecular mechanisms at individual synapses remain unclear.

    Conclusions:

    • Current memory storage mechanisms are not fully understood at the individual synapse level.
    • Further research is needed to delineate neuronal connectivity mechanisms at the chemical level.
    • Inter- or intramolecular bonding patterns at the synaptic level may be vital for memory storage.