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Comparison of nanoparticle penetration into solid tumors and sites of inflammation: studies using targeted and

Scott Poh1,2, Venkatesh Chelvam1,3, Philip S Low1

  • 11Department of Chemistry, Purdue University, West Lafayette, IN 47907, USA.

Nanomedicine (London, England)
|May 22, 2015
PubMed
Abstract

Insights

Nanoparticle delivery agents accumulate better in inflammatory sites than solid tumors. This suggests nanomedicines may be more effective for treating inflammatory diseases than cancer.

Area of Science:

  • Nanomedicine
  • Oncology
  • Immunology

Background:

  • Nanomedicine research heavily focuses on cancer diagnosis and treatment.
  • Solid tumors' dense extracellular matrix hinders nanoparticle penetration.
  • This raises questions about nanomedicines' optimal applications in oncology.

Purpose of the Study:

  • To compare nanoparticle uptake in tumors versus inflammatory lesions.
  • To investigate the potential of nanomedicines beyond oncology.

Main Methods:

  • Utilized folate-conjugated liposomes for targeted delivery.
  • Compared liposome uptake in folate receptor-expressing tumors and inflammatory lesions within the same mouse model.

Main Results:

  • Both targeted and nontargeted liposomes showed higher accumulation at inflammatory sites compared to solid tumors.
  • Demonstrated differential accumulation based on lesion type, not solely targeting.

Conclusions:

  • Nanosized agents may be more suitable for diagnosing and treating inflammatory and autoimmune diseases.
  • Current nanomedicine applications might be better directed away from solid tumors.
  • Suggests a paradigm shift in nanomedicine research focus.
Keywords:
cancerfolateinflammationliposomenanomedicinenanoparticle

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