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Related Experiment Video

Updated: Apr 12, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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The stroke-migraine depolarization continuum.

Jens P Dreier1, Clemens Reiffurth2

  • 1Department of Neurology, Charité University Medicine Berlin, 10117 Berlin, Germany; Department of Experimental Neurology, Charité University Medicine Berlin, 10117 Berlin, Germany; Center for Stroke Research, Charité University Medicine Berlin, 10117 Berlin, Germany.

Neuron
|May 22, 2015
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Summary

Spreading depolarization (SD) involves rapid ion shifts in brain gray matter. This review explores SD

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Area of Science:

  • Neuroscience
  • Neurology

Background:

  • Spreading depolarization (SD) describes mass depolarization waves in central nervous system gray matter.
  • SD involves rapid neuronal ion gradient breakdown, triggered by hypoxia and linked to neuronal death.
  • SD is implicated in migraine aura and conditions like stroke and brain trauma.

Purpose of the Study:

  • To review the neurobiology of spreading depolarization (SD).
  • To examine SD triggers and propagation mechanisms.
  • To discuss clinical manifestations, diagnostic advancements, and treatments for SD.

Main Methods:

  • Literature review of spreading depolarization (SD).
  • Analysis of SD's role in various neurological conditions.
  • Overview of recent neuromonitoring developments.

Main Results:

  • SD has diverse triggers and propagation pathways.
  • SD continuum ranges from benign migraine aura to severe stroke.
  • Neuromonitoring shows promise for improved SD diagnosis and treatment.

Conclusions:

  • Understanding SD's neurobiology is crucial for neurological disease management.
  • Differentiating SD in migraine versus stroke is clinically significant.
  • Advancements in neuromonitoring offer new therapeutic avenues for SD.