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Updated: Apr 12, 2026

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Akt1 phosphorylates Nicastrin to regulate its protein stability and activity

Eun-Hye Jo1, Ji-Seon Ahn1, Jung-Soon Mo1

  • 1Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.

Journal of Neurochemistry
|May 22, 2015
PubMed
Summary

Akt1 kinase activity degrades Nicastrin (NCT), a key gamma-secretase component. This phosphorylation-dependent process inhibits gamma-secretase activity, impacting amyloid precursor protein processing.

Keywords:
Akt1Nicastrinco-localizationlysosomephosphorylationproteasome

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