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Gastritis-II: Pathophysiology01:17

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
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Related Experiment Video

Updated: Apr 12, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Autoimmunity in patients with selective IgA deficiency.

H Abolhassani, B Gharib, S Shahinpour

    Journal of Investigational Allergology & Clinical Immunology
    |May 23, 2015
    PubMed
    Summary

    Selective immunoglobulin A deficiency (SIgAD) is linked to higher rates of autoimmune disorders. This study found associations between autoimmunity in SIgAD patients and longer follow-up, higher IgM, regulatory T-cells, and memory B-cells.

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    Area of Science:

    • Immunology
    • Primary Immunodeficiencies
    • Autoimmunity

    Background:

    • Selective immunoglobulin A deficiency (SIgAD) is the most common primary antibody deficiency.
    • Patients with SIgAD exhibit an increased risk of developing autoimmune disorders.
    • The underlying mechanisms connecting SIgAD and autoimmunity require further elucidation.

    Purpose of the Study:

    • To investigate the relationship between autoimmunity and specific clinical or immunological markers in patients with SIgAD.
    • To identify factors associated with the development of autoimmune complications in SIgAD.
    • To understand the progression of autoimmune SIgAD.

    Main Methods:

    • Studied 57 symptomatic patients with confirmed SIgAD.
    • Collected demographic data and family history of autoimmunity.
    • Conducted comprehensive clinical and laboratory examinations for autoimmune complications.

    Main Results:

    • Autoimmune disorders were present in 29.8% of patients, with thyroiditis, vitiligo, and hemolytic anemia being most common.
    • Associations found between autoimmunity and longer follow-up, elevated IgM, regulatory T-cells, and class-switched memory B-cells.
    • Four patients (23.5%) progressed to common variable immunodeficiency.

    Conclusions:

    • Autoimmune disorders, cytopenias, and Ig subclass deficiencies can cause severe symptoms in SIgAD patients.
    • Clinicians should be vigilant for autoimmune conditions in individuals with SIgAD.
    • Early recognition and management are crucial for better patient outcomes.