Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Extracellular Matrix01:29

The Extracellular Matrix

13.7K
Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
13.7K
The Extracellular Matrix01:42

The Extracellular Matrix

91.3K
Overview
91.3K
Bone Remodeling01:40

Bone Remodeling

41.2K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
41.2K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

4.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
4.8K
The Bone Matrix01:18

The Bone Matrix

10.1K
Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
10.1K
Extracellular Matrix01:26

Extracellular Matrix

6.7K
Unlike epithelial tissue, which is composed of cells closely packed with little or no extracellular space in between, connective tissue cells are dispersed in a matrix. This extracellular matrix (ECM) is composed of fibrous proteins like collagen, elastin, and fibronectin in a ground substance consisting of interstitial fluid, cell adhesion proteins, and proteoglycans. The proteoglycans form a gel-like material in the spaces between cells and provide hydration, buffering, binding, and force...
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Thrombospondin-2 deficiency primes the synovial joint for aberrant tissue remodeling and injury response.

bioRxiv : the preprint server for biology·2026
Same author

Wnt/β-catenin signaling regulates fibrotic atrophy of intra-articular adipose tissue in post-traumatic osteoarthritis.

bioRxiv : the preprint server for biology·2026
Same author

Murine model of high bone mass osteogenesis imperfecta exhibits bone matrix hyper-mineralization, misaligned mineral crystals, and altered osteoblast differentiation.

Bone research·2026
Same author

Spatial transcriptomic profiling of decalcified murine musculoskeletal samples via Xenium Prime 5K.

JBMR plus·2026
Same author

Jagged ligand expression by alpha-SMA progenitors is required for normal fracture healing.

Bone·2026
Same author

The Role of Wnt Signaling in Age-Related Alveolar Bone Loss and Regeneration.

Journal of periodontal research·2026

Related Experiment Video

Updated: Apr 12, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K

Extracellular matrix networks in bone remodeling.

Andrea I Alford1, Kenneth M Kozloff1, Kurt D Hankenson2

  • 1Department of Orthopaedic Surgery, School of Medicine, University of Michigan, United States.

The International Journal of Biochemistry & Cell Biology
|May 23, 2015
PubMed
Summary
This summary is machine-generated.

Bone

Keywords:
BoneExtracellular matrixOsteoblastOsteoclastOsteocyte

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.6K

Related Experiment Videos

Last Updated: Apr 12, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.8K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.2K
A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix
09:40

A Rapid, Scalable Method for the Isolation, Functional Study, and Analysis of Cell-derived Extracellular Matrix

Published on: January 4, 2017

17.6K

Area of Science:

  • Bone Biology
  • Biomaterials Science
  • Cellular Biology

Background:

  • Bone remodeling is a continuous process vital for skeletal integrity.
  • Dysfunctional bone remodeling leads to diseases like osteoporosis and osteosclerosis.
  • The bone extracellular matrix (ECM) is crucial for regulating bone remodeling by osteoblasts and osteoclasts.

Purpose of the Study:

  • To review the multifaceted roles of extracellular matrix (ECM) protein networks in bone remodeling.
  • To explore how ECM influences osteoblast and osteoclast activities and their interplay.
  • To consider the clinical implications of ECM networks in bone pathologies.

Main Methods:

  • This is a comprehensive review article.
  • It synthesizes existing literature on bone ECM composition and function.
  • The review focuses on cell-ECM interactions and signaling pathways.

Main Results:

  • The bone ECM acts as a scaffold for mineralization and provides structural flexibility.
  • ECM components regulate the differentiation and function of osteoblasts and osteoclasts.
  • ECM modulates cell-cell communication and growth factor activity, influencing bone remodeling.

Conclusions:

  • ECM protein networks are critical regulators of bone remodeling.
  • Understanding ECM dynamics is essential for developing novel therapeutic strategies for bone loss and other bone diseases.
  • Targeting ECM interactions offers potential for treating bone pathologies.