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Updated: Aug 12, 2026

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency
Published on: June 16, 2011
Hb Luxembourg [alpha 24(B5) Tyr----His]: a new unstable variant
P Groff1, F Galacteros, G Kalmes
1Division d'Hématologie, Laboratoire National de Santé, Luxembourg.
Abstract:
Hb Luxembourg [alpha 24(B5)Tyr----His] was found in association with mild hemolytic anemia and increased indirect bilirubinemia in a family originating from the Netherlands. The slight instability of this variant may be the consequence of an indirect effect of the substitution on the alpha 1 beta 1 contact since position alpha 24 (B5) is internal and in contact with several residues involved in this interface.
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