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Published on: October 23, 2020
β-Blocker Use and Risk of Recurrence in Patients with Early Breast Cancer
Minas Sakellakis1, Anastasia Kostaki, Ioannis Starakis
1Division of Oncology, Department of Medicine, University Hospital, Patras Medical School, Rion, Greece.
Aim:
We evaluated whether the concurrent β-blocker use in early breast cancer patients influenced the outcome in terms of preventing tumor recurrence after adjuvant chemotherapy.
Methods:
We retrospectively reviewed the medical records of 610 patients with breast cancer. Thereafter, we compared overall disease-free survival (DFS) between β-blocker users and nonusers.
Results:
Those not receiving β-blockers had a relatively longer mean DFS (10.8 vs. 9.7 years), although the difference did not reach statistical significance (p = 0.651). When the survival analysis was adjusted for age, tumor stage, hormone receptor status and HER2 status, the results remained unaltered, suggesting that β-blocker use did not significantly improve overall DFS (HR, 0.849; 95% CI, 0.537-1.343; p = 0.485).
Conclusion:
Our findings failed to confirm previous results indicating a potential antitumor effect of β-blockers.
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