Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

1.3K
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.3K
Diphtheria01:28

Diphtheria

114
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
114
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

1.1K
The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
1.1K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

457
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
457
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

69.8K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
69.8K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

4.8K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guidance on the management of asymptomatic blood donors who test positive for Babesia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2025
Same author

Ganciclovir Dosing in Premature Infants Receiving Treatment for Congenital Cytomegalovirus Infection: Results of a Prospective Pharmacokinetic Study.

The Journal of infectious diseases·2025
Same author

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA): 2020 Guideline on Diagnosis and Management of Babesiosis.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2021
Same author

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2021
Same author

Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA), American Academy of Neurology (AAN), and American College of Rheumatology (ACR): 2020 Guidelines for the Prevention, Diagnosis and Treatment of Lyme Disease.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2021
Same author

Clinical Practice Guidelines by the Infectious Diseases Society of America, American Academy of Neurology, and American College of Rheumatology: 2020 Guidelines for the Prevention, Diagnosis, and Treatment of Lyme Disease.

Neurology·2020

Related Experiment Video

Updated: Apr 12, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
07:20

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

18.9K

Lyme disease in children.

Sunil K Sood1

  • 1Hofstra North Shore-LIJ School of Medicine, Hempstead, NY 11549, USA; Department of Pediatrics, Southside Hospital, 301 East Main Street, Bay Shore, NY 11706, USA; Pediatric Infectious Diseases, Cohen Children's Medical Center, New Hyde Park, NY 11040, USA.

Infectious Disease Clinics of North America
|May 23, 2015
PubMed
Summary

Lyme disease in children shares adult treatment protocols but requires avoiding doxycycline in those under 8. Early detection of elevated intracranial pressure is crucial to prevent vision loss in pediatric Lyme disease.

Keywords:
ChildrenIncreased intracranial pressureLyme meningitisOptic nerveTick bite managementTick bite prevention

More Related Videos

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.9K
Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
09:54

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

12.2K

Related Experiment Videos

Last Updated: Apr 12, 2026

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR
07:20

Detecting the Lyme Disease Spirochete, Borrelia Burgdorferi, in Ticks Using Nested PCR

Published on: February 4, 2018

18.9K
Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research
08:23

Feeding of Ticks on Animals for Transmission and Xenodiagnosis in Lyme Disease Research

Published on: August 31, 2013

13.9K
Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut
09:54

Methods for Rapid Transfer and Localization of Lyme Disease Pathogens Within the Tick Gut

Published on: February 14, 2011

12.2K

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Lyme disease is a growing public health concern, particularly in pediatric populations.
  • Understanding age-specific nuances in Lyme disease diagnosis and management is critical for effective pediatric care.
  • Tick-borne illnesses require vigilant prevention and prompt treatment strategies.

Purpose of the Study:

  • To outline the diagnosis and management of Lyme disease in children.
  • To highlight key differences in pediatric Lyme disease care compared to adults.
  • To provide guidance on serologic testing and prevention of tick bites in children.

Main Methods:

  • Review of current clinical guidelines and literature on pediatric Lyme disease.
  • Analysis of age-specific treatment recommendations, particularly regarding antibiotic choices.
  • Emphasis on recognizing and managing specific pediatric presentations like elevated intracranial pressure.

Main Results:

  • Lyme disease diagnosis and management in children largely mirrors adult protocols, with notable exceptions.
  • Doxycycline is contraindicated as an initial empiric treatment for children aged 8 years and younger.
  • Children may develop insidious elevated intracranial pressure during acute disseminated Lyme disease, necessitating prompt intervention to preserve vision.
  • Pediatric patients with Lyme disease, including late disseminated Lyme arthritis, generally have an excellent prognosis.
  • Guidance on appropriate use of serologic tests is provided.

Conclusions:

  • Pediatric Lyme disease management requires specific considerations, particularly antibiotic selection for younger children.
  • Awareness of potential complications like elevated intracranial pressure is vital for preventing long-term sequelae.
  • Pediatricians and family practitioners must be proficient in the prevention and management of tick bites and Lyme disease in children.