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Complete Genome Sequence of Streptococcus thermophilus SMQ-301, a Model Strain for Phage-Host Interactions

Simon J Labrie1, Denise M Tremblay1, Pier-Luc Plante2

  • 1Département de Biochimie, de Microbiologie, et de Bio-Informatique, Faculté des Sciences et de Génie, Groupe de Recherche en Écologie Buccale, Faculté de Médecine Dentaire, Félix d'Hérelle Reference Center for Bacterial Viruses, Université Laval, Québec, Canada.

Genome Announcements
|May 23, 2015
PubMed

Insights

The genome of Streptococcus thermophilus SMQ-301 was sequenced, revealing its genetic makeup. This bacterium is crucial for producing yogurt and cheeses, and understanding its genome aids in dairy production and phage resistance research.

Area of Science:

  • Microbiology
  • Genomics
  • Food Science

Background:

  • Streptococcus thermophilus is a key bacterium in the dairy industry, essential for fermenting milk into products like yogurt and cheese.
  • This specific strain, S. thermophilus SMQ-301, is known to be a host for several virulent bacteriophages, posing challenges to industrial applications.

Purpose of the Study:

  • To sequence and characterize the complete genome of Streptococcus thermophilus SMQ-301.
  • To provide a genomic resource for understanding phage-host interactions and improving dairy fermentation processes.

Main Methods:

  • Whole genome sequencing was performed using both PacBio and Illumina sequencing platforms.
  • Bioinformatic analyses were conducted to assemble the genome and identify genes, tRNAs, and rRNAs.

Main Results:

  • The complete genome of S. thermophilus SMQ-301 was assembled, measuring 1,861,792 base pairs.
  • The genome contains 2,037 protein-coding genes, 67 transfer RNA (tRNA) genes, and 18 ribosomal RNA (rRNA) genes.

Conclusions:

  • The sequenced genome of S. thermophilus SMQ-301 provides valuable genetic information for dairy microbiology.
  • This genomic data can facilitate research into phage resistance mechanisms and enhance the efficiency of industrial fermentation processes.

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