Design, fabrication, and packaging of an integrated, wirelessly-powered optrode array for optogenetics application.

Area of Science:

• Neuroscience
• Biomedical Engineering
• Materials Science

Background:

• Optogenetics requires advanced tools for precise neural circuit modulation.
• Existing optogenetic tools face limitations in power delivery, size, and biocompatibility for chronic use.

Purpose of the Study:

• To design, fabricate, and package a wirelessly-powered, LED-coupled optrode neural interface for optogenetic applications.
• To develop a scalable, cost-effective, and biocompatible system for neural modulation and recording.

Main Methods:

• Utilized microscale LEDs (μLEDs) and polymer microwaveguides for light delivery to cortical networks.
• Integrated microelectrodes for simultaneous neural activity recording.
• Developed an implantable switched-capacitor based stimulator (SCS) system with inductive power transfer.

Main Results:

• Demonstrated a mechanically flexible, biocompatible, miniaturized, and lightweight optrode array.
• Achieved wireless power delivery enabling sufficient light emission for neural activation.
• Showcased scalability and cost-effectiveness through microelectromechanical systems (MEMS) batch fabrication.

Conclusions:

• The developed LED-coupled optrode neural interface is suitable for chronic implantation in small freely behaving animals.
• The system offers a versatile platform for optogenetic studies, adaptable for various experimental needs.
• This technology advances engineering tools for optical modulation of neural circuitry.