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Updated: Apr 12, 2026

Parallel Measurement of Circadian Clock Gene Expression and Hormone Secretion in Human Primary Cell Cultures
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Circadian Clocks and the Interaction between Stress Axis and Adipose Function.

Isa Kolbe1, Rebecca Dumbell1, Henrik Oster1

  • 1Chronophysiology Group, Medical Department I, University of Lübeck, 23538 Lübeck, Germany.

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Summary

Daily rhythms, or circadian rhythms, are controlled by internal clocks. These clocks in the adrenal glands and adipose tissue interact, influencing metabolic disorders and stress responses.

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Area of Science:

  • Endocrinology
  • Chronobiology
  • Metabolic Physiology

Background:

  • Physiological processes and endocrine functions exhibit daily fluctuations, known as circadian rhythms.
  • These rhythms are driven by endogenous cellular clocks, adapting organisms to predictable environmental changes.
  • Circadian clocks are present in the stress axis and adipose tissue, regulating hormones like glucocorticoids and adipokines.

Purpose of the Study:

  • To review the current understanding of adrenal and adipose tissue clocks and rhythms.
  • To explore the reciprocal interactions between these clock systems.
  • To discuss their roles in energy homeostasis, stress responses, and metabolic disorders.

Main Methods:

  • Literature review of studies on circadian rhythms in adrenal and adipose tissues.
  • Analysis of research on the interaction between stress axis and adipose clocks.
  • Synthesis of findings related to metabolic and stress disorders.

Main Results:

  • Adrenal and adipose tissue clocks exhibit rhythmic functions, influencing hormone release.
  • Reciprocal interactions between adrenal and adipose clock systems are suggested.
  • These interactions may play a significant role in metabolic regulation and stress response.

Conclusions:

  • Circadian rhythms in adrenal and adipose tissues are crucial for physiological adaptation.
  • Interactions between these clocks are implicated in metabolic disorders.
  • Potential chronotherapeutic strategies targeting these rhythms may offer new treatment avenues.