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Trop2 and its overexpression in cancers: regulation and clinical/therapeutic implications

Anna Shvartsur1, Benjamin Bonavida1

  • 1Department of Microbiology, Immunology and Molecular Genetics, Jonsson Comprehensive Cancer Center and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA.

Genes & Cancer
|May 23, 2015
PubMed

Insights

Trop2 (TROP2) is a protein overexpressed in many cancers, driving tumor growth and drug resistance. Targeting Trop2 shows promise for cancer therapy and as a prognostic biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Trop2 (TROP2) is a transmembrane glycoprotein involved in cell signaling, proliferation, and survival.
  • While expressed in normal tissues, Trop2 is significantly overexpressed in various cancers, correlating with poor prognosis.
  • Trop2 overexpression in cancer cells is linked to drug resistance, highlighting its clinical relevance.

Purpose of the Study:

  • To review the characteristics of cancer cells overexpressing Trop2.
  • To explore Trop2's potential as a prognostic biomarker.
  • To discuss Trop2 as a therapeutic target for overcoming drug resistance.

Main Methods:

  • Literature review of studies on Trop2 function, expression, and therapeutic targeting.
  • Analysis of Trop2's role in cancer cell signaling pathways and drug resistance mechanisms.
  • Examination of preclinical and clinical data for Trop2-targeted therapies.

Main Results:

  • Trop2 overexpression is associated with cancer stem cell-like properties, promoting self-renewal, proliferation, and invasion.
  • Multiple therapeutic strategies targeting Trop2, including antibodies and fusion proteins, have shown efficacy in preclinical models.
  • A clinical trial is evaluating IMMU-132 for epithelial cancers, demonstrating ongoing therapeutic development.

Conclusions:

  • Trop2 is a significant biomarker for cancer prognosis and a promising therapeutic target.
  • Targeting Trop2 offers a potential strategy to reverse drug resistance and improve patient outcomes.
  • Further research and clinical evaluation of Trop2-based therapies are warranted.

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