Related Experiment Video
Updated: Apr 12, 2026
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Subtype-dependent Morphological and Functional Degeneration of Retinal Ganglion Cells in Mouse Models of Experimental
Zhen Puyang1, Hui Chen2, Xiaorong Liu3
1Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA ; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Abstract:
In this short review, Puyang and her colleagues compared the results from three laboratories on the dendritic and functional degeneration of retinal ganglion cells (RGCs) in mouse models of experimental glaucoma [1-4]. Acute or chronic ocular hypertension was induced in mice, and different techniques were applied to identify RGC types. The dendritic alternations of RGCs were examined following the induction of ocular hypertension, and their light response properties were characterized by the multi-electrode array (MEA) recording. These studies support the notion that the morphological and functional degeneration of RGCs are subtype-dependent in experimental glaucoma.
