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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

125
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Modified-Release Drug Delivery Systems: Site-Targeted01:24

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Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
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Aptamer-functionalized nanoparticles for drug delivery.

Bo Liu, Jiani Zhang, Jie Liao

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    |May 23, 2015
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    Aptamer-conjugated nanoparticles offer advanced biomedical applications. This review highlights recent developments in aptamer-mediated drug delivery using nanoparticle conjugation for improved therapeutics and diagnostics.

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    Area of Science:

    • Biomedical Engineering
    • Nanotechnology
    • Molecular Biology

    Background:

    • Aptamers are DNA/RNA molecules with high affinity and specificity for diverse targets.
    • Nanoparticles possess unique properties like small size and high surface area, beneficial for medicine.
    • Combining aptamers and nanoparticles creates novel therapeutic and diagnostic tools.

    Purpose of the Study:

    • To review recent advancements in aptamer-mediated drug delivery.
    • To explore the conjugation of aptamers with various nanoparticles for therapeutic applications.

    Main Methods:

    • In vitro selection and amplification (SELEX) for aptamer synthesis.
    • Conjugation of aptamers with nanoparticles.
    • Review of recent literature on aptamer-nanoparticle drug delivery systems.

    Main Results:

    • Aptamer-nanoparticle conjugates show promise in early diagnosis and targeted drug delivery.
    • These systems overcome limitations of traditional therapeutic and diagnostic agents.
    • Dissociation constants for selected aptamers range from nanomolar to picomolar.

    Conclusions:

    • Aptamer-nanoparticle conjugates represent a significant advancement in nanomedicine.
    • They offer enhanced opportunities for developing next-generation therapeutics and diagnostics.
    • Further research in this area holds potential for improved patient outcomes.