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Updated: Apr 12, 2026
Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Long-decay near-infrared-emitting doped quantum dots for lifetime-based in vivo pH imaging
Chi Chen1, Pengfei Zhang, Li Zhang
1Guangdong Key Laboratory of Nanomedicine, CAS Key Laboratory of Health Informatics, Shenzhen Bioactive Materials Engineering Lab for Medicine, Institute of Biomedicine and Biotechnology Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, P. R. China. lt.cai@siat.ac.cn.
Abstract:
pH-responsive doped quantum dots with an ultrasmall size (∼3.5 nm), near-infrared emission (∼720 nm) and long lifetime (∼1 μs), which exhibit a linear response range from pH 5.5 to 7.0 with the maximum change in the fluorescence lifetime up to ∼600 nm, were synthesized as lifetime-based pH nanosensors for in vivo imaging.
