Association between angiotensin-converting enzyme insertion/deletion polymorphism and migraine: a meta-analysis

Area of Science:

• Genetics
• Neurology
• Pharmacogenomics

Background:

• The association between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism and migraine has been investigated in numerous studies.
• However, the results of these studies are controversial, necessitating further evaluation.

Purpose of the Study:

• To conduct a meta-analysis to clarify the correlation between the ACE I/D polymorphism and migraine.
• To evaluate the potential protective or risk effects of ACE gene variants on migraine development.

Main Methods:

• A systematic literature search was performed for studies published up to September 2014.
• Meta-analysis was conducted using pooled odds ratios (ORs) and 95% confidence intervals (CIs) with random-effects models.

Main Results:

• The meta-analysis included 14 studies with 7334 migraineurs and 22,990 controls.
• No significant association was found between the ACE I/D polymorphism and migraine overall.
• A protective effect of the ACE II genotype against migraine with aura and without aura was observed in the Turkish population.

Conclusions:

• The ACE II genotype may confer a protective effect against both migraine with aura and migraine without aura.
• This protective effect appears to be specific to the Turkish population.