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The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis

Yan G Zhao1, Le Sun, Guangyan Miao

  • 1a State Key Laboratory of Biomacromolecules; Institute of Biophysics; Chinese Academy of Sciences ; Beijing , China.

Autophagy
|May 23, 2015
PubMed

Keywords:
ACTB, β-actinAMC, aminomethylcoumarinAtg, autophagy-relatedBPAN, β-propeller protein-associated neurodegenerationCALB, calbindinCNS, central nervous systemDCN, deep cerebellar nucleiEi24, etoposide-induced gene 24GFAP, glial fibrillary acid proteinH&E, hematoxylin and eosinKO, knockoutLC3, microtubule-associated protein 1 light chain 3LTP, long-term potentiationMBP, myelin basic proteinNBIA, neurodegeneration with brain iron accumulationRBFOX3, RNA binding protein, fox-1 homolog (C. elegans) 3SENDA, static encephalopathy of childhood with neurodegeneration in adulthoodSQSTM1, sequestosome-1WDR5/WIPI4, WD repeat domain 45WT, wild type.Wdr45/Wipi4autophagyaxon swellingepg, ectopic P granulefEPSP, field excitatory postsynaptic potentiallearning and memoryneurodegenerationrpm, rotations per min

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