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A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
Pulmonary embolism in children
11 Department of Radiology and Radiological Science, Medical University of South Carolina, MSC 322, 96 Jonathan Lucas St, Charleston, SC 29425.
Insights
Pediatric pulmonary thromboembolism (PE) is increasingly recognized. This review covers PE in children, focusing on diagnosis, treatment, and the crucial role of advanced imaging techniques like CT and MRI.
Area of Science:
- Pediatric Radiology
- Cardiovascular Imaging
- Pulmonology
Background:
- Pediatric pulmonary thromboembolism (PE) is an under-recognized condition.
- Limited literature exists on pediatric PE, necessitating a comprehensive review.
Purpose of the Study:
- To bridge the knowledge gap in pediatric PE.
- To provide a comprehensive review of epidemiology, pathophysiology, diagnosis, and treatment.
- To discuss future directions in imaging research for pediatric PE.
Main Methods:
- Literature review and synthesis of current knowledge on pediatric PE.
- Discussion of diagnostic modalities including nonimaging and imaging examinations.
- Exploration of treatment strategies and prognostic factors.
Main Results:
- PE in children requires a multidisciplinary approach.
- Imaging is central to diagnosis, with CT and MRI being key modalities.
- Emerging CT techniques and MRI offer improved diagnostic capabilities.
Conclusions:
- Imaging is critical for diagnosing pediatric PE.
- CT remains a primary tool, with dual-energy CT showing promise.
- MRI presents a radiation-free alternative with high diagnostic accuracy.
Objective:
Pediatric pulmonary thromboembolism (PE) has historically been considered a rare entity with relatively little published in the medical literature. The purpose of this article is to bridge some of the current knowledge gap regarding PE by presenting a comprehensive review of the topic, including discussion of its epidemiology, pathophysiology, clinical manifestations, nonimaging diagnostic examinations, imaging evaluation, treatment and prognosis, and future imaging research directions.
Conclusion:
Imaging plays a key role in the evaluation of pediatric PE, and imaging technology will continue to improve. CT will likely remain a first-line diagnostic modality with newer techniques such as dual-energy CT having the potential to become more widely used while improving sensitivity and specificity for small and distal PE. Alternatively, given its lack of ionizing radiation and high sensitivity and specificity when technically adequate, MRI is appealing and may become a viable first-line substitute to CT.
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Pneumothorax-II
Clinical Manifestations:

