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Chromosomal rearrangements involving the NTRK1 gene in colorectal carcinoma

Laurent Créancier1, Isabelle Vandenberghe1, Bruno Gomes1

  • 1Centre de Recherche en Oncologie Expérimentale, Institut de Recherche Pierre Fabre, 3 Avenue Hubert Curien BP13562, 31035 Toulouse Cedex 1, France.

Cancer Letters
|May 24, 2015
PubMed

Insights

NTRK1 gene rearrangements, including TPM3-NTRK1 and TPR-NTRK1 fusions, are recurring oncogenic events in colorectal cancer, found in approximately 0.5% of cases. These alterations activate the TRKA receptor, contributing to cancer development.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Chromosomal rearrangements involving the NTRK1 gene, encoding the tropomyosin related kinase A (TRKA) receptor, are implicated in various epithelial cancers.
  • NTRK1 fusions result in constitutive TRKA kinase activation, driving oncogenesis.

Purpose of the Study:

  • To investigate the presence and frequency of NTRK1 gene rearrangements in colorectal cancer.
  • To identify novel NTRK1 fusions in colorectal tumors.

Main Methods:

  • Analysis of human colorectal cancer samples using immunohistochemistry.
  • Quantitative reverse transcriptase PCR to detect NTRK1 gene rearrangements.

Main Results:

  • Identified NTRK1 rearrangements in two out of 408 colorectal cancer cases (approximately 0.5%).
  • One case showed a TPM3-NTRK1 fusion, previously observed in colon cancer.
  • A novel TPR-NTRK1 fusion was identified in the second case.

Conclusions:

  • NTRK1 gene translocations are recurring, albeit infrequent, events in colorectal cancer.
  • The identified fusions lead to oncogenic TRKA activation.
  • Further research into NTRK1 rearrangements in colorectal cancer is warranted.
Keywords:
Colon cancerGene rearrangementNTRK1TRKA

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