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Updated: Apr 12, 2026
06:23
Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
5.6K
Juvenile spondyloarthritis.
Sabrina Gmuca1, Pamela F Weiss
1aDivision of Rheumatology, The Children's Hospital of Philadelphia bDepartment of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Current Opinion in Rheumatology
|May 24, 2015
Summary
Juvenile spondyloarthritis (JSpA) research reveals new insights into pathogenesis and pain perception. While treatments like TNF inhibitors show promise, achieving inactive disease remains challenging for affected children.
Area of Science:
- Rheumatology
- Pediatric Immunology
- Genetics and Microbiome Research
Background:
- Juvenile spondyloarthritis (JSpA) is a complex inflammatory condition affecting children.
- Understanding its pathogenesis, diagnosis, and management is crucial for improving patient outcomes.
- Existing knowledge gaps necessitate updated reviews on JSpA.
Purpose of the Study:
- To provide a comprehensive update on juvenile spondyloarthritis (JSpA).
- To cover pathogenesis, diagnostic imaging, treatments, and disease activity measurements.
- To synthesize recent findings and identify future research directions.
Main Methods:
- Review of recent genetic and microbiome studies.
- Analysis of current treatment guidelines and therapeutic efficacy.
- Evaluation of newly developed disease activity measures for JSpA.
Main Results:
- Genetic and microbiome research offers new insights into JSpA pathogenesis.
- Children with JSpA exhibit altered pain thresholds; physical exam findings and ultrasound are not well correlated.
- TNF inhibitors show symptomatic efficacy for axial disease, but long-term structural damage effects are unclear; achieving inactive disease is difficult in JSpA.
Conclusions:
- Further research into microbiome and genetics is essential for understanding JSpA pathogenesis.
- The development of new composite disease activity measures is needed.
- More randomized therapeutic trials are required to advance JSpA treatment.
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