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Aeroallergen contact can exacerbate atopic dermatitis: patch tests as a diagnostic tool
1Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.
Journal of the American Academy of Dermatology
|October 1, 1989
Summary
Environmental aeroallergens can trigger atopic dermatitis flares. Removing patients from allergen exposure and avoiding specific aeroallergens led to significant skin symptom improvement in this study.
Area of Science:
- Dermatology
- Allergology
- Immunology
Background:
- Atopic dermatitis (AD) is a chronic inflammatory skin condition.
- Food allergens are known triggers for AD flares.
- The role of environmental aeroallergens in AD exacerbation requires further investigation.
Purpose of the Study:
- To investigate the role of aeroallergen contact in triggering atopic dermatitis flares.
- To evaluate the efficacy of aeroallergen avoidance in managing AD symptoms.
Main Methods:
- Prick testing was performed on 12 patients with AD using various aeroallergen extracts.
- Positive prick test responders underwent patch testing with relevant aeroallergens.
- Skin reactions were assessed at 48 and 72 hours post-application.
Main Results:
- All 12 patients exhibited immediate positive reactions to specific aeroallergens via prick testing.
- Patch testing revealed eczematous eruptions in response to relevant aeroallergens at 48 and 72 hours.
- Patients who avoided identified aeroallergens showed marked improvement or resolution of their dermatitis.
Conclusions:
- Aeroallergen contact is a significant factor in exacerbating atopic dermatitis in susceptible individuals.
- Delayed cutaneous reactions on patch testing correlate with environmental aeroallergens.
- Aeroallergen avoidance is an effective management strategy for select patients with atopic dermatitis.