Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

221
Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
221
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

777
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
777
Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence01:19

Pharmaceutical Alternatives: Excipients and Impurities-Related Therapeutic Nonequivalence

228
Pharmaceutical products contain more than just the active drug; they also contain various excipients such as binders, solubilizers, stabilizers, preservatives, and other elements. In some cases, impurities or contaminants might be present. Traditionally, quality control in pharmaceuticals has primarily focused on the analysis of the active drug, often overlooking the impact of these additional components. The recent issue with heparin contamination by over-sulfated chondroitin sulfate, a...
228
Drug-Receptor Interactions01:29

Drug-Receptor Interactions

8.5K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
8.5K
Complexation Equilibria: Overview01:23

Complexation Equilibria: Overview

1.7K
Complexation reactions take place when dative or coordinate covalent bonds form between metal ions and ligands. The compounds formed in these reactions are called coordination compounds. The number of bonds formed between the metal ion and the ligands is called its coordination number. Generally, most metal ions in an aqueous solution are solvated by water molecules and thus exist as aqua complexes.
The equilibrium constant of the complexation reaction is represented as the formation constant...
1.7K
Drug-Receptor Bonds01:25

Drug-Receptor Bonds

5.4K
Drug-receptor bonds are formed through various chemical forces when drugs interact with target cells. Covalent bonds, strong and irreversible, are exemplified by DNA-alkylating anticancer agents that inhibit cell division. However, such irreversible drug binding lacks selectivity and can modify the DNA of the surrounding healthy cells. Covalent binding often contributes to tissue toxicity, as seen with chloroform and paracetamol metabolites binding to the liver, causing hepatotoxicity.
In...
5.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural diversity and unity amongst axonemal dynein assembly factors.

Journal of cell science·2025
Same author

Post-LECA Origin and Diversification of an Axonemal Outer Arm Dynein Motor.

Cytoskeleton (Hoboken, N.J.)·2025
Same author

Cilia biology: Building the central pair apparatus tip.

Current biology : CB·2025
Same author

Isoform-specific phosphorylation of axonemal dynein heavy chains.

Molecular biology of the cell·2025
Same author

Steric Complementarity Drives Strong Co-Assembly of Short Peptide Stereoisomers.

Journal of the American Chemical Society·2025
Same author

<i>Chlamydomonas</i> FBB18 is a ubiquitin-like protein essential for the cytoplasmic preassembly of various ciliary dyneins.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Apr 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.9K

Probing competitive interactions in quaternary formulations.

Omar T Mansour1, Beatrice Cattoz1, Richard K Heenan2

  • 1Faculty of Science and Engineering, University of Greenwich, Medway Campus, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.

Journal of Colloid and Interface Science
|May 24, 2015
PubMed
Summary

Alcohols tune interactions between poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) block copolymers and surfactants, altering mixed micelle shape and size. Longer alcohols create larger micelles, while shorter alcohols decrease micelle size.

Keywords:
PGSE-NMRPluronic micelleSANSSmall molecule surfactant

More Related Videos

Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.8K
Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.5K

Related Experiment Videos

Last Updated: Apr 12, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

11.9K
Diagonal Method to Measure Synergy Among Any Number of Drugs
12:08

Diagonal Method to Measure Synergy Among Any Number of Drugs

Published on: June 21, 2018

19.8K
Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.5K

Area of Science:

  • Colloid and Surface Science
  • Polymer Chemistry
  • Materials Science

Background:

  • Amphiphilic block copolymers like poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) self-assemble into micelles in aqueous solutions.
  • These copolymer micelles can interact with small molecule surfactants, leading to complex self-assembled structures.
  • The presence of alcohols can significantly influence these interactions and the resulting micelle morphology.

Purpose of the Study:

  • To investigate how short, medium, and long-chain alcohols affect the interactions between Pluronic P123 (a PEO-PPO-PEO copolymer) and different types of small molecule surfactants (anionic SDS, cationic C12TAB, non-ionic Brij 35).
  • To understand the role of alcohol partitioning in determining micelle composition and morphology.
  • To elucidate the impact of these interactions on mixed micelle formation and characteristics.

Main Methods:

  • Tensiometry was used to measure surface tension and infer interaction strengths.
  • Pulsed-gradient spin-echo nuclear magnetic resonance (PGSE-NMR) was employed to estimate micelle composition and component partitioning.
  • Small-angle neutron scattering (SANS) was utilized to determine micelle morphology and size.

Main Results:

  • Small-angle neutron scattering (SANS) data for P123 solutions with alcohols were consistent with a charged core/shell micelle model.
  • Addition of surfactants to P123 solutions resulted in smaller, oblate elliptical mixed micelles without alcohols.
  • Ethanol addition decreased micelle size, while hexanol and decanol addition led to larger micelles, indicating alcohol chain length-dependent effects on micelle morphology.

Conclusions:

  • Alcohols act as 'tuning agents' for the interactions between PEO-PPO-PEO copolymers and small molecule surfactants.
  • The length of the alcohol chain influences the partitioning of components and the resulting mixed micelle morphology, ranging from smaller micelles with ethanol to larger ones with longer alcohols.
  • These findings provide insights into controlling self-assembly in complex surfactant-polymer systems.