Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Barriers to Effective Communication I01:30

Barriers to Effective Communication I

12.5K
A communication barrier is any distortion or interruption during a conversation, resulting in miscommunication of the message. A good communicator should know these barriers and continuously check for the listener's understanding by obtaining feedback.
Communication barriers include the following:
Physiological barriers: They are limitations caused by a person's health condition or disability, such as hearing loss, poor eyesight, illness, or unconsciousness. An example to overcome this...
12.5K
Barriers to Effective Communication II01:21

Barriers to Effective Communication II

5.7K
The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
5.7K
Physiological Barriers01:25

Physiological Barriers

5.7K
Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...
5.7K
Schemas01:42

Schemas

12.5K
A schema is a mental construct consisting of a cluster or collection of related concepts (Bartlett, 1932). There are many different types of schemata, and they all have one thing in common: schemata are a method of organizing information that allows the brain to work more efficiently. When a schema is activated, the brain makes immediate assumptions about the person or object being observed.
12.5K
Natural and Artificial Concepts01:24

Natural and Artificial Concepts

725
In psychology, concepts can be divided into two categories: natural and artificial. Natural concepts are formed through direct or indirect experiences. For example, consider the concept of snow. If you live in a place with regular snowfall, such as Essex Junction, Vermont, you know snow through direct experiences. You’ve seen it fall, touched it, shoveled it, and played in it. You recognize its texture, appearance, and even its smell. In contrast, if you live on an island like Saint...
725
Factors Affecting Perception01:25

Factors Affecting Perception

3.2K
Perception is influenced by perceptual set, context, motivation, and emotion. Perceptual set, or perceptual expectancy, refers to the tendency to perceive things in a particular way, influenced by previous experiences and expectations. This phenomenon affects the interpretation of stimuli, creating a set of mental tendencies and assumptions that impact sensory perceptions of sound, taste, touch, and sight.
An illustrative example of a perceptual set is the scenario where an airline pilot told...
3.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Chronic Atrophic Gastritis to Low-Grade Intraepithelial Neoplasia: A Proteomic Study on the Sequential Progression of Gastric Precancerous Lesions.

Journal of gastroenterology and hepatology·2026
Same author

Epithelial MLCK deficiency alleviates alcohol-associated liver disease via dendritic-Th17 cell axis.

JHEP reports : innovation in hepatology·2026
Same author

The end of 'leaky gut': pathway-specific mechanistic approaches to barrier restoration.

Current opinion in gastroenterology·2026
Same author

Tolebrutinib Phase 2b Long-Term Extension Study: Two-Year Safety, MRI, and Clinical Efficacy Outcomes in Patients With Relapsing Multiple Sclerosis Patients.

Neurology open access·2026
Same author

Macrophage-derived cathepsin B disrupts intestinal tight junctions through occludin degradation and promotes alcohol-associated liver disease.

Journal of hepatology·2026
Same author

Targeting MLCK1 uncouples immune checkpoint inhibitor-induced colitis from antitumour immunity.

Gut·2026

Related Experiment Video

Updated: Apr 12, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.7K

Conceptual barriers to understanding physical barriers.

Amulya Lingaraju1, Tiha M Long1, Yitang Wang1

  • 1Department of Pathology, The University of Chicago, United States.

Seminars in Cell & Developmental Biology
|May 25, 2015
PubMed
Summary

Claudins regulate paracellular channels and tight junction assembly. This review explores claudin roles in barrier function, suggesting lipids form the tight junction seal.

Keywords:
BarrierClaudinLipidMembrane microdomainTight junction

More Related Videos

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

6.4K
Applying Incongruent Visual-Tactile Stimuli during Object Transfer with Vibro-Tactile Feedback
05:43

Applying Incongruent Visual-Tactile Stimuli during Object Transfer with Vibro-Tactile Feedback

Published on: May 23, 2019

6.0K

Related Experiment Videos

Last Updated: Apr 12, 2026

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers
18:57

Models and Methods to Evaluate Transport of Drug Delivery Systems Across Cellular Barriers

Published on: October 17, 2013

47.7K
Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions
06:54

Methods for Presenting Real-world Objects Under Controlled Laboratory Conditions

Published on: June 21, 2019

6.4K
Applying Incongruent Visual-Tactile Stimuli during Object Transfer with Vibro-Tactile Feedback
05:43

Applying Incongruent Visual-Tactile Stimuli during Object Transfer with Vibro-Tactile Feedback

Published on: May 23, 2019

6.0K

Area of Science:

  • Cell Biology
  • Biochemistry
  • Physiology

Background:

  • Claudins are key proteins in the tight junction, regulating paracellular transport.
  • They form selective channels for ions and water.
  • Their role in forming the tight junction seal is still debated.

Purpose of the Study:

  • To review the current understanding of claudin functions in tight junction structure and barrier.
  • To propose a model for claudin involvement in tight junction strand formation.

Main Methods:

  • Literature review of existing studies on claudins and tight junctions.
  • Analysis of ultrastructural and biochemical data.
  • Synthesis of findings to propose a structural model.

Main Results:

  • Claudins are essential for forming selective paracellular channels.
  • Claudins contribute to tight junction strand assembly and protein recruitment.
  • Evidence suggests lipids play a crucial role in forming the paracellular seal.

Conclusions:

  • Claudins are integral to tight junction function, mediating selective transport.
  • A model is proposed where claudins drive the assembly of lipid-based tight junction strands.
  • Lipid structures are likely responsible for the paracellular seal, stabilized by claudins.