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Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
Published on: March 30, 2018
11.8K
Primary mantle cell lymphoma of appendix.
V L Gaopande1, S D Deshmukh1, V C Shinde2
1Department of Pathology, Smt Kashibai Navale Medical College and Hospital, Pune, Maharashtra, India.
The Gulf Journal of Oncology
|May 25, 2015
Summary
This study details a rare case of primary mantle cell lymphoma in the appendix, presenting as a right iliac fossa mass. This contrasts with typical gastrointestinal mantle cell lymphoma presentations.
Area of Science:
- Oncology
- Gastroenterology
- Pathology
Background:
- Mantle cell lymphoma (MCL) is an uncommon non-Hodgkin lymphoma.
- Gastrointestinal involvement by MCL often presents as lymphomatous polyposis.
- Primary appendiceal lymphoma is exceedingly rare.
Purpose of the Study:
- To report a unique case of primary mantle cell lymphoma originating in the appendix.
- To highlight an atypical presentation of gastrointestinal mantle cell lymphoma.
- To emphasize the diagnostic utility of immunohistochemistry in classifying rare lymphomas.
Main Methods:
- Histopathological examination of the appendix.
- Immunohistochemical staining to confirm cell lineage and markers.
- Clinical and radiological assessment of the presenting mass.
Main Results:
- Immunohistochemistry confirmed primary mantle cell lymphoma of the appendix.
- The patient presented with a mass in the right iliac fossa, not typical lymphomatous polyposis.
- Mantle cell lymphoma exhibits distinct immunohistochemical and genetic profiles.
Conclusions:
- Primary mantle cell lymphoma of the appendix is a rare entity.
- Appendiceal MCL can present as a focal mass, diverging from typical GI presentations.
- Immunohistochemistry is crucial for accurate diagnosis and classification of rare MCL cases.
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