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Related Experiment Video

Updated: Apr 12, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Rare chromosome structural aberration characterizing oncology malignancy.

A Movafagh¹, A Sayad¹, M Hashemi²

¹Department of Medical Genetics, Pediatric Neurology Research Center, Mofid Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

The Gulf Journal of Oncology

|May 25, 2015

Summary

Ring chromosome aberrations are rare in oncology patients. This study highlights a specific case of ring chromosome 15 associated with chronic myeloid leukemia (CML), adding to the understanding of these genetic abnormalities in cancer.

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Area of Science:

Oncology
Cytogenetics
Cancer Genetics

Background:

Ring chromosome aberrations are uncommon genetic abnormalities found in oncology patients.
These aberrations can involve any chromosome and are associated with various malignancies.

Purpose of the Study:

To review literature on ring chromosomes in oncology.
To present a case study of a patient with a ring chromosome associated with malignancy.

Main Methods:

Systematic electronic literature search using CINAHL, Google Scholar, and PubMed.
Inclusion of original quantitative research published in English.
Cytogenetic analysis of bone marrow specimen using GTG-banding technique.

Main Results:

Ring chromosome observed in 10% of cells.
Cytogenetic analysis revealed a ring chromosome 15 (r(15)) karyotype (46, XY, r(15)).
Clinical findings included symptoms consistent with accelerated chronic myeloid leukemia (CML).

Conclusions:

The findings contribute to the understanding of ring chromosome morphology and genetic rearrangements in oncology.
Further research is needed to establish firm conclusions regarding ring chromosomes in malignancies.