Related Experiment Video
Updated: Apr 12, 2026

Cholesterol Efflux Assay
Published on: March 6, 2012
Something important is missing in the ACC/AHA cholesterol treatment guidelines
Insights
The 2013 American College of Cardiology/American Heart Association cholesterol guidelines lack clinical guidance, hindering adoption. The National Lipid Association offers recommendations to aid clinicians in managing atherosclerotic cardiovascular disease risk.
Area of Science:
- Cardiology
- Lipidology
- Public Health
Background:
- The 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines were developed to reduce atherosclerotic cardiovascular disease (ASCVD).
- Despite evidence-based foundations, widespread clinical adoption has been limited.
- A significant gap exists in practical guidance for clinicians and patient understanding.
Purpose of the Study:
- To examine the factors influencing the development of the 2013 ACC/AHA cholesterol guidelines.
- To identify reasons for the delayed adoption of these guidelines by healthcare providers.
- To highlight the need for practical recommendations in clinical practice.
Main Methods:
- Review of the development process of the 2013 ACC/AHA cholesterol guidelines.
- Analysis of clinician feedback and adoption barriers.
- Evaluation of the content and structure of the guidelines.
Main Results:
- The 2013 ACC/AHA guidelines, while evidence-based, lack actionable guidance for managing dyslipidemias.
- This absence of clear direction impedes the translation of scientific evidence into clinical practice.
- Clinicians and patients require more accessible information for effective cholesterol management.
Conclusions:
- The National Lipid Association (NLA) has provided recommendations to address the guidance gap in cholesterol management.
- NLA recommendations offer expert direction for clinicians in treating patients at risk of ASCVD.
- These recommendations aim to facilitate the successful management of cholesterol levels and improve patient outcomes.
Objective:
To discuss factors surrounding development of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol guidelines and reasons they have not yet been adopted by clinicians.
Summary:
The new ACC/AHA cholesterol guidelines were released in November 2013. The guidelines are based on randomized controlled trial evidence and, if fully implemented, are likely to result in a reduction of atherosclerotic cardiovascular disease (ASCVD) in Americans. Despite this, the guidelines have not been adopted by clinicians. This is because the guidelines are missing something very important-guidance for the clinician and the public. Guidelines are supposed to give guidance to clinicians on how to manage the various clinical presentations encountered in daily practice and to help them translate science into practice. Guidelines are also supposed to help the public define dyslipidemias in a way they can understand and thus seek treatment and actively follow the progress of their treatment.
Conclusion:
The National Lipid Association (NLA) stepped in to help fill the void in the ACC/AHA cholesterol guidelines and offered recommendations for treating individual patients who have increased risk of ASCVD. The NLA recommendations give clinicians the expert guidance and LDL-C goal rudder they need to successfully manage their patient's cholesterol.
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