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Related Concept Videos

Anatomical Positions01:11

Anatomical Positions

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In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
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Equilibrium and Balance01:15

Equilibrium and Balance

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The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
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Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

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Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
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Fatigue01:21

Fatigue

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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Normal and Tangetial Components: Problem Solving01:24

Normal and Tangetial Components: Problem Solving

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Consider a man with a mass of 70 kg seated in a chair connected to a pin support through a member BC. If the man maintains an upright position, the task is to determine the horizontal and vertical reactions of the chair on the man when the member makes a 45° angle with the horizontal. At this moment, the man has a speed of 5 m/s, increasing at a rate of 1 m/s².
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Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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Related Experiment Video

Updated: Apr 12, 2026

Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study
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Quantifying Arms and Legs Contributions during Repetitive Electrically-Assisted Sit-To-Stand Exercise in Paraplegics: A Pilot Study

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Sick of sitting.

James A Levine1

  • 1Mayo Clinic, 13400 East Shea Blvd, Scottsdale, AZ, 85259, USA, levine.james@mayo.edu.

Diabetologia
|May 25, 2015
PubMed
Summary

Excessive sitting, or "sitting disease," is linked to obesity and over 30 chronic diseases. Reimagining environments to encourage walking can reverse this sedentary trend for better health.

Area of Science:

  • Public Health
  • Preventive Medicine
  • Human Physiology

Background:

  • Sedentary lifestyles are a growing concern in modern society.
  • Excessive sitting is associated with significant health risks, including obesity and numerous chronic diseases.
  • Modern life has led to a decrease in daily physical activity compared to pre-industrial times.

Purpose of the Study:

  • To highlight the detrimental health effects of excessive sitting.
  • To emphasize that "sitting disease" is a reversible condition.
  • To propose environmental modifications that promote physical activity.

Main Methods:

  • Review of epidemiological, physiological, and molecular data.
  • Analysis of the association between sedentary behavior and chronic diseases.

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  • Exploration of potential solutions for mitigating the impact of excessive sitting.

    • Main Results:

    • Sedentary behavior is a significant contributing factor to obesity and over 30 chronic diseases.
    • High healthcare costs are linked to conditions exacerbated by excessive sitting.
    • Current lifestyles involve substantially less movement than in pre-industrial eras.

    Conclusions:

    • Excessive sitting poses a major threat to public health.
    • Re-engineering environments to facilitate walking is a viable strategy to combat "sitting disease."
    • Promoting active lifestyles through environmental changes can lead to improved health, happiness, and productivity.