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Systemic endothelial function in cases with wet-type age-related macular degeneration
Hasan Basri Arifoglu1, Arzu Seyhan Karatepe Hashas2, Mustafa Atas2
1Ophthalmology Department, S.B. Kayseri Research and Education Hospital, Sanayi Mah. Atatürk Boulevard Hastane Street No:78, Kayseri, 38010, Turkey. habasa@yahoo.com.
Background:
Choroidal endothelial dysfunction plays key role in wet-type age-related macular degeneration (AMD). Peripheral vascular endothelial function is not known in wet AMD.
Objective:
We aimed to analyze peripheral vascular endothelial function in cases with wet-type age-related macular degeneration by measuring flow-mediated dilatation (FMD).
Materials And Methods:
The study included 20 cases with wet AMD (Group 1, mean age 65.9 ± 7.2 years) and 24 healthy individuals (Group 2, mean age 62.0 ± 11.9 years). In all cases, a cardiologist assessed the responses of endothelial function by measuring the FMD following brachial artery occlusion.
Results:
Mean FMD, an indicator of endothelial function was found to be 6.4 ± 2.7 % in Group 1 and 15.6 ± 7.3 % in Group 2 (p < 0.001). There was no significant difference between patient and control groups regarding age, sex, total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride, ESR and CRP.
Conclusion:
Reduced FMD is present in patients with wet AMD, suggesting that impaired peripheral endothelial function may be involved in its pathogenesis.
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