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Updated: Apr 12, 2026

Application of Biolayer Interferometry BLI for Studying Protein-Protein Interactions in Transcription
Published on: July 26, 2019
Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old
Sandhya S Visweswariah1, Stephen J W Busby2
1Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore 560012, India.
Abstract:
Many bacterial transcription factors do not behave as per the textbook operon model. We draw on whole genome work, as well as reported diversity across different bacteria, to argue that transcription factors may have evolved from nucleoid-associated proteins. This view would explain a large amount of recent data gleaned from high-throughput sequencing and bioinformatic analyses.
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