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Restless leg syndrome and multiple sclerosis: a case-control study in China
Gangqiong Liu1,2, Xiao Feng3, Chao Lan4
1Institute of Clinical Medicine, Department of Urology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jian She Dong Avenue, Zhengzhou, 450002, People's Republic of China.
Sleep & Breathing = Schlaf & Atmung
|May 25, 2015
Summary
Restless leg syndrome (RLS) is more common in multiple sclerosis (MS) patients. This condition significantly impacts sleep quality in those with MS.
Area of Science:
- Neurology
- Sleep Medicine
- Epidemiology
Background:
- Restless leg syndrome (RLS) is a common neurological disorder.
- RLS frequently co-occurs in patients with multiple sclerosis (MS).
- The precise relationship between RLS and MS remains under investigation.
Purpose of the Study:
- To determine the prevalence of RLS in patients with MS.
- To investigate the association between RLS and MS.
- To identify risk factors associated with RLS in MS patients.
Main Methods:
- A case-control study design was employed.
- 695 MS patients and 603 healthy controls were recruited.
- Data on RLS incidence and sleep quality were collected via interviews.
Main Results:
- RLS prevalence was significantly higher in MS patients (OR=3.8, P<0.001).
- Older age at MS onset and longer MS duration were linked to RLS.
- MS patients with RLS reported more sleep complaints.
Conclusions:
- RLS is significantly associated with multiple sclerosis.
- RLS presence negatively impacts sleep quality in MS patients.
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