Proton pump (H+/K+-ATPase) expression in human larynx
Siniša Stevanović1, Radivoje Radić2, Željka Perić Kačarević2
1(Medical Faculty Osijek), Clinical Hospital "Sisters of Mercy" Zagreb (ENT Dept), Vinogradska 29, 10000 Zagreb, Croatia.
Auris, Nasus, Larynx
|May 25, 2015
Summary
Researchers identified the proton pump in the larynx, suggesting it may produce acid locally. This finding opens new avenues for understanding laryngeal diseases and cartilage disorders.
Area of Science:
- Laryngology
- Gastroenterology
- Cell Biology
Background:
- Acidic content in the larynx is linked to various laryngeal diseases.
- Acid reflux from the stomach is a common cause, but local laryngeal acid production is also suspected.
- Proton pumps are key in acid production.
Purpose of the Study:
- To investigate the presence and location of proton pumps within the larynx.
- To determine if the larynx itself can produce acid, contributing to laryngeal conditions.
Main Methods:
- The study analyzed 50 cadaver larynges and 11 surgical larynges.
- Samples were collected from the supraglottic, glottic, and subglottic regions.
- Immunohistochemistry was used to detect the beta subunit of the proton pump.
Main Results:
- Proton pumps were confirmed in the seromucous glands of the laryngeal supraglottic area.
- For the first time, proton pumps were detected in human chondrocytes within the thyroid and epiglottic cartilage.
- This indicates potential for local acid production within laryngeal cartilage.
Conclusions:
- The presence of proton pumps in laryngeal cartilage is a novel finding.
- This discovery may enhance understanding of the causes of laryngopharyngeal reflux.
- Further research is warranted to explore the role of these findings in cartilage-related disorders.
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