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Updated: Apr 12, 2026

Development of Recombinant Proteins to Treat Chronic Pain
Published on: April 11, 2018
In vivo and systems biology studies implicate IL-18 as a central mediator in chronic pain
Kiran Vasudeva1, Yoram Vodovotz2, Nabil Azhar2
1Department of Biological Sciences, Duquesne University, Pittsburgh, PA 15282, USA; Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA 15282, USA.
None:
Inflammation is associated with peripheral neuropathy, however the interplay among cytokines, chemokines, and neurons is still unclear. We hypothesized that this neuroinflammatory interaction can be defined by computational modeling based on the dynamics of protein expression in the sciatic nerve of rats subjected to chronic constriction injury. Using Dynamic Bayesian Network inference, we identified interleukin (IL)-18 as a central node associated with neuropathic pain in this animal model. Immunofluorescence supported a role for inflammasome activation and induction of IL-18 at the site of injury. Combined in vivo and in silico approaches may thus highlight novel targets in peripheral neuropathy.
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